{"product_id":"ambrettolide-macrocyclic-musk-givaudan","title":"Ambrettolide – Macrocyclic Musk by Givaudan | Perfumery Raw Material","description":"\u003ch2\u003eAmbrettolide – Macrocyclic Musk by Givaudan\u003c\/h2\u003e\n\u003ch2\u003ePerfumery Raw Material\u003c\/h2\u003e\n\n\u003cp\u003eAmbrettolide takes its name from ambrette seed – and the connection between the two lies not only in the name. The character of the material also differs from many other musks.\u003c\/p\u003e\n\n\u003cp\u003eOn the blotter, Ambrettolide often seems surprisingly restrained. No sharp edges, no dominant musk cloud, no immediately recognizable signature. Only within a composition does the material's true strength emerge – it rarely changes a fragrance through volume, but by feeling like a natural part of its development rather than an added component.\u003c\/p\u003e\n\n\u003cp\u003eIts character stays closer to skin than to fabric. This is precisely what makes Ambrettolide special: the material does not create distance, it shortens it. This gives rise to compositions that feel immediate, familiar and self-evident.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eOdor profile of Ambrettolide\u003c\/h2\u003e\n\u003cp\u003eAmbrettolide is perceived as:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003esoft musk\u003c\/li\u003e\n\u003cli\u003eambrette facets\u003c\/li\u003e\n\u003cli\u003esubtle fruity nuances (berry, pear)\u003c\/li\u003e\n\u003cli\u003esilky transparency\u003c\/li\u003e\n\u003cli\u003egentle warmth\u003c\/li\u003e\n\u003cli\u003efine musk structure\u003c\/li\u003e\n\u003cli\u003erestrained sensuality\u003c\/li\u003e\n\u003cli\u003eskin closeness\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThe scent recalls the soft side of musk – not cleanliness, not freshness, but warmth, skin and a calm musky radiance. According to Givaudan, the odor threshold is 1.97 ng\/L – Ambrettolide is thus perceptible even in the finest traces. On the blotter it remains perceptible for a month according to Givaudan.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eWhat is Ambrettolide used for in perfumery?\u003c\/h2\u003e\n\u003cp\u003eAmbrettolide is often used when musk should be perceptible without shifting the fragrance toward a fresh accord or textile associations. Typical applications are musk accords, skin-scent perfumes, floral compositions, white-flower accords and amber compositions. The usage range, according to Givaudan, is traces to 2%.\u003c\/p\u003e\n\u003cp\u003eThe material is suited to soft base structures, supports the drydown and improves the tenacity of a formula. It is used in women's, men's and unisex perfumery as well as in body-care products, deodorants, antiperspirants, shampoo, hair care, soaps and other care products. Givaudan rates burning effectiveness as well as substantivity (wet and dry) each as \"Good.\"\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eSpecial properties\u003c\/h2\u003e\n\u003cp\u003eAmbrettolide combines transparency with high persistence. The material remains perceptible on blotters for a long time and changes its character only slightly in the process. Added to this are good diffusion and pronounced substantivity.\u003c\/p\u003e\n\u003cp\u003eDespite its persistence, Ambrettolide rarely feels heavy. The musk effect remains clearly recognizable without displacing other components of a composition. It is precisely this combination of tenacity, transparency and skin closeness that distinguishes Ambrettolide from many other musk materials.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eA note on the designation\u003c\/h2\u003e\n\u003cp\u003eThe Ambrettolide offered here is – as with practically all commercial suppliers (IFF, Givaudan, Symrise) – correctly designated as iso-ambrettolide. The musk that actually occurs naturally in ambrette seed carries a different CAS number (7779-50-2) and is occasionally – incorrectly – equated with this material. Both share important olfactory properties but are not identical.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eMacrocyclic musk – why the molecular class matters\u003c\/h2\u003e\n\u003cp\u003eAmbrettolide belongs to the class of macrocyclic musk lactones – chemically and ecologically a different family from the better-known polycyclic musk compounds such as Galaxolide or Tonalide.\u003c\/p\u003e\n\u003cp\u003eAccording to the Givaudan safety data sheet, Ambrettolide is readily biodegradable – 84% degradation after 28 days (OECD 301F, GLP-tested). It is not classified as a PBT or vPvB substance and shows no endocrine-disrupting properties.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eRegulatory note\u003c\/h2\u003e\n\u003cp\u003eAmbrettolide (CAS 28645-51-4) is not subject to any quantity restriction under the IFRA 51st Amendment – not even in Category 4 (fine fragrance). Under Regulation (EC) No. 1272\/2008 it is not classified as a hazardous substance.\u003c\/p\u003e\n\u003cp\u003eIn Germany, Ambrettolide is classified as WGK 2 (significantly hazardous to water) – do not allow to enter waterways or drains. It is not listed on the REACH SVHC candidate list.\u003c\/p\u003e\n\u003cp\u003eCheck current IFRA Standards and EU regulations before use in commercial products.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eSafety\u003c\/h2\u003e\n\u003cp\u003eAccording to the Givaudan safety data sheet:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAcute oral toxicity: LD50 rat \u0026gt;5000 mg\/kg\u003c\/li\u003e\n\u003cli\u003eAcute dermal toxicity: LD50 rabbit \u0026gt;5000 mg\/kg\u003c\/li\u003e\n\u003cli\u003eSkin sensitization: non-sensitizing (1% in petrolatum, human)\u003c\/li\u003e\n\u003cli\u003ePhototoxicity: negative (guinea pig)\u003c\/li\u003e\n\u003cli\u003eNo endocrine-disrupting properties\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003ePhysico-chemical properties\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\u003ctr\u003e\n\u003cth\u003eProperty\u003c\/th\u003e\n\u003cth\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eManufacturer\u003c\/td\u003e\n\u003ctd\u003eGivaudan\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProduct name\u003c\/td\u003e\n\u003ctd\u003eAmbrettolide\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eChemical name\u003c\/td\u003e\n\u003ctd\u003eOxacycloheptadec-10-en-2-one\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFragrance family\u003c\/td\u003e\n\u003ctd\u003emusky \/ fruity \/ floral\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePerfumery role\u003c\/td\u003e\n\u003ctd\u003ebase note, fixative, musk structural material\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMaterial form\u003c\/td\u003e\n\u003ctd\u003ecolorless to pale-yellow liquid\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC₁₆H₂₈O₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e252.4 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eDensity at 20°C\u003c\/td\u003e\n\u003ctd\u003e953.3 kg\/m³\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRefractive index nD20\u003c\/td\u003e\n\u003ctd\u003e1.4791\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFlash point\u003c\/td\u003e\n\u003ctd\u003e169°C (ISO 2719)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAuto-ignition temperature\u003c\/td\u003e\n\u003ctd\u003e260°C (DIN 51794)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBoiling point\u003c\/td\u003e\n\u003ctd\u003e307°C at 1013 hPa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eVapor pressure\u003c\/td\u003e\n\u003ctd\u003e\u0026lt;1.0 hPa at 20°C\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eOdor threshold\u003c\/td\u003e\n\u003ctd\u003e1.97 ng\/L\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater solubility\u003c\/td\u003e\n\u003ctd\u003e6 mg\/L\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eLog Pow\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;6.0 (OECD 117)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eTenacity on blotter\u003c\/td\u003e\n\u003ctd\u003e1 month\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eUsage range\u003c\/td\u003e\n\u003ctd\u003eTraces – 2%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e≥97.0% (ISO 7609, polar)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage\u003c\/td\u003e\n\u003ctd\u003e10–30°C, dry, protected from light, tightly closed\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS no.\u003c\/td\u003e\n\u003ctd\u003e28645-51-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEC no.\u003c\/td\u003e\n\u003ctd\u003e249-120-7\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eREACH registration number\u003c\/td\u003e\n\u003ctd\u003e01-2120103324-74\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eFEMA\u003c\/td\u003e\n\u003ctd\u003e4145\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eBiodegradability\u003c\/td\u003e\n\u003ctd\u003e84% after 28 days (OECD 301F)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eWater hazard class (WGK)\u003c\/td\u003e\n\u003ctd\u003e2 (significantly hazardous to water)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIFRA status\u003c\/td\u003e\n\u003ctd\u003eno quantity restriction, not even in fine fragrance\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003eWhat is Ambrettolide?\u003c\/strong\u003e\u003cbr\u003e\nAmbrettolide is a synthetic macrocyclic musk by Givaudan with a soft, fruity-floral character close to the natural musk of ambrette seed oil – without being chemically identical to it.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eIs Ambrettolide the same as the musk from ambrette seed?\u003c\/strong\u003e\u003cbr\u003e\nNo, not exactly. The commercially available material is more precisely designated as iso-ambrettolide. The musk that occurs naturally in ambrette seed carries a different CAS number (7779-50-2). Both share important olfactory properties but are not identical.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eAre there IFRA restrictions for Ambrettolide?\u003c\/strong\u003e\u003cbr\u003e\nNo. Ambrettolide is not subject to any quantity IFRA restriction, not even in fine fragrance (Category 4).\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow does Ambrettolide differ from polycyclic musk compounds?\u003c\/strong\u003e\u003cbr\u003e\nAmbrettolide belongs to the class of macrocyclic musk lactones. According to Givaudan it is readily biodegradable (84% after 28 days) – a clear difference from many polycyclic musk compounds.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eHow long does the scent of Ambrettolide last?\u003c\/strong\u003e\u003cbr\u003e\nAccording to Givaudan, one month on the blotter at dosages of traces to 2%.\u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eIs Ambrettolide hazardous to water?\u003c\/strong\u003e\u003cbr\u003e\nIn Germany it is classified as WGK 2 – do not allow to enter waterways or drains. At the same time it is readily biodegradable and not classified as a PBT substance.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eHazard Information (CLP Labelling)\u003c\/h2\u003e\n\u003cdiv style='border:1px solid #d0d0d0;border-radius:8px;padding:16px;max-width:640px;'\u003e\n\u003cp\u003e\u003cstrong\u003eNot classified as hazardous\u003c\/strong\u003e under Regulation (EC) No 1272\/2008 (CLP), as amended. No hazard pictogram, signal word or hazard statements (H phrases) required.\u003c\/p\u003e\n\u003cp style='font-size:13px;color:#555;'\u003eSubstance: Ambrettolide (CAS 28645-51-4). The legally binding labelling appears on the packaging.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eImportant note\u003c\/h2\u003e\n\u003cp\u003eThis product is a perfumery raw material intended exclusively for fragrance development, creative experimentation, education and the study of perfumery materials.\u003c\/p\u003e\n\u003cp\u003eIt is not a finished cosmetic product.\u003c\/p\u003e\n\u003cp\u003ePlease use responsibly.\u003c\/p\u003e","brand":"Givaudan","offers":[{"title":"10 ml","offer_id":53087681970512,"sku":"AMBT-10","price":30.0,"currency_code":"EUR","in_stock":true},{"title":"20 ml","offer_id":53087682003280,"sku":"AMBT-20","price":46.0,"currency_code":"EUR","in_stock":true},{"title":"100 ml","offer_id":53087682036048,"sku":"AMBT-100","price":190.0,"currency_code":"EUR","in_stock":true},{"title":"300 ml","offer_id":53087682068816,"sku":"AMBT-300","price":394.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0902\/1341\/7296\/files\/Ambrofix_e0e7d9fe-bfa2-46ee-b2aa-6726af92be32.jpg?v=1780389181","url":"https:\/\/laborammeer.de\/en\/products\/ambrettolide-macrocyclic-musk-givaudan","provider":"Labor am Meer","version":"1.0","type":"link"}