{"product_id":"hedione-hc-dsm-firmenich","title":"Hedione® HC (dsm-firmenich) – High-Cis Methyl Dihydrojasmonate","description":"\u003ch2\u003eHedione® HC – dsm-firmenich\u003c\/h2\u003e\n\u003cp\u003eHedione® HC is the same methyl dihydrojasmonate (CAS 24851-98-7) as classic Hedione – but with a different ratio of the four stereoisomers. Only one of them, the (+)-cis isomer, carries virtually all of the odor. In classic Hedione it makes up around 10%; in Hedione HC, considerably more. Hence the strength, the longer tenacity and the lower dosage range.\u003c\/p\u003e\n\n\u003ch2\u003eOdor Profile\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e“A unique powerful, floral note reminiscent of magnolia blossoms.” (official manufacturer description) – a powerful floral note reminiscent of magnolia blossoms\u003c\/li\u003e\n\u003cli\u003eOfficial descriptors: Floral, Jasmine, Citrus\u003c\/li\u003e\n\u003cli\u003eTop and heart note\u003c\/li\u003e\n\u003cli\u003eOdor threshold of the (+)-cis isomer: 15 ppb. For comparison: the strongest of the three remaining isomers sits 16 times higher (240 ppb), the weakest around 1000 times higher (Werkhoff et al., Food Reviews International, 2002)\u003c\/li\u003e\n\u003cli\u003eTenacity on the blotter: about 1 month (classic Hedione: about 2 weeks)\u003c\/li\u003e\n\u003cli\u003ePhysical form: pale straw-colored to yellowish oily liquid\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003eRole in the Formula\u003c\/h2\u003e\n\u003cp\u003eThe strength of Hedione HC is not a marketing claim but a direct consequence of chemistry: one isomer outstrips the other three in odor intensity by orders of magnitude, and HC contains a higher share of it. Accordingly, less material is needed for the same or a stronger effect: 7–25% versus 12–38% for classic \u003ca href=\"\/en\/products\/hedione-firmenich\"\u003eHedione®\u003c\/a\u003e in fine fragrance.\u003c\/p\u003e\n\u003cp\u003eThe professional assessment is more nuanced than the marketing. Perfumer Arcadi Boix Camps describes Hedione HC in the trade journal Perfumer \u0026 Flavorist (2004) as “good” but “less pleasurable” than classic Hedione, which he describes as “flowing, flying, diffusing with charm and grace.” Pure strength, then, is not the same as pure quality – the material is worth testing in your own formula, not just judging by dosage numbers.\u003c\/p\u003e\n\n\u003ch2\u003eWhy pH Matters\u003c\/h2\u003e\n\u003cp\u003eThe manufacturer's condition of a neutral pH (5.5–7.0) is a direct consequence of the same chemistry that gives Hedione HC its strength. The cis isomer is thermodynamically less stable than the trans isomer and, in the presence of a base, rapidly converts to the weaker trans form – already documented in the 1971 cis-enrichment patent, where complete conversion is achieved by refluxing for two hours in alkaline sodium methoxide solution. Hedione HC is therefore unsuitable for soap and strongly alkaline bases: there, the expensive cis form epimerizes back, and the invested strength is lost.\u003c\/p\u003e\n\n\u003ch2\u003eUse in Perfumery\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eFine fragrance: 7–25% (classic Hedione: 12–38%)\u003c\/li\u003e\n\u003cli\u003eShampoo: 0.8–4%\u003c\/li\u003e\n\u003cli\u003eShower gel: 2–10%\u003c\/li\u003e\n\u003cli\u003eCandles: 2–5%\u003c\/li\u003e\n\u003cli\u003eOnly for bases with pH 5.5–7.0; not for soap or alkaline media\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch2\u003ePractical Notes: Dissolving, Storage, Pairing\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDissolving:\u003c\/strong\u003e Liquid and directly dosable; soluble in oils and ethanol, only very sparingly soluble in water.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Cool, dry, protected from light and tightly closed.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePairing:\u003c\/strong\u003e Jasmine, white flowers, magnolia, citrus top notes. In the trade literature, Hedione is also traditionally paired with musk materials, whose diffusion it enhances. Not for soap or other alkaline bases.\u003c\/p\u003e\n\n\u003ch2\u003eThe Race for One Isomer\u003c\/h2\u003e\n\u003cp\u003eCis-enrichment was not first patented by Firmenich but by a competitor: in 1971 the French company Roure Bertrand Fils et Justin Dupont (later part of Givaudan) obtained a patent on methyl dihydrojasmonate with at least 90% cis content, made by hydrogenation in the presence of an aluminium catalyst. Firmenich responded with its own cis-enriched qualities, and in the 1990s Zeon (Cepionate) joined this race with another approach. The manufacturer does not publish the exact cis content of Hedione HC.\u003c\/p\u003e\n\u003cp\u003eThe pinnacle of this development is Paradisone: a nearly pure (+)-cis isomer, produced by asymmetric hydrogenation on a ruthenium catalyst (Firmenich patent, Dobbs, Vanhessche, Rautenstrauch et al., Angewandte Chemie, 2000). Paradisone is a Firmenich captive material and is not available on the open market. The full story of this race is on our encyclopedia page \u003ca href=\"\/en\/pages\/hedione-hc\"\u003eHedione® HC: The Race for One Isomer\u003c\/a\u003e.\u003c\/p\u003e\n\n\u003ch2\u003eSafety Information\u003c\/h2\u003e\n\u003cp\u003eAccording to the RIFM assessment (Api et al., Food and Chemical Toxicology, 2015), the material is not sensitizing, not genotoxic and not phototoxic; the NOAEL for repeated dosing is 100 mg\/kg\/day with a margin of exposure (MOE) of 256. No IFRA Standard exists for CAS 24851-98-7. It is not on the allergen list under Annex III of the EU Cosmetics Regulation. According to the manufacturer's data it is not classified as hazardous.\u003c\/p\u003e\n\n\u003ch2\u003ePhysico-Chemical Properties\u003c\/h2\u003e\n\u003ctable\u003e\u003ctbody\u003e\n\u003ctr\u003e\u003ctd\u003eManufacturer\u003c\/td\u003e\u003ctd\u003edsm-firmenich\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eProduct name\u003c\/td\u003e\u003ctd\u003eHedione® HC\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eProduct code\u003c\/td\u003e\u003ctd\u003e947325\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFragrance family\u003c\/td\u003e\u003ctd\u003eFloral (descriptors: Floral, Jasmine, Citrus)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eRole in perfumery\u003c\/td\u003e\u003ctd\u003eTop and heart note, booster\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003ePhysical form\u003c\/td\u003e\u003ctd\u003ePale straw-colored to yellowish oily liquid\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eMolecular formula\u003c\/td\u003e\u003ctd\u003eC13H22O3\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eMolecular weight\u003c\/td\u003e\u003ctd\u003e226.32 g\/mol\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eCAS No.\u003c\/td\u003e\u003ctd\u003e24851-98-7\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eEC No.\u003c\/td\u003e\u003ctd\u003e246-495-9\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eREACH registration\u003c\/td\u003e\u003ctd\u003e01-2119493355-31\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eLog P\u003c\/td\u003e\u003ctd\u003e2.94\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eWater solubility\u003c\/td\u003e\u003ctd\u003eVery sparingly soluble (soluble in oils and ethanol)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eDensity\u003c\/td\u003e\u003ctd\u003e0.997–1.008 (20°C, literature value)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eRefractive index\u003c\/td\u003e\u003ctd\u003e1.454–1.464 (literature value)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eFlash point\u003c\/td\u003e\u003ctd\u003e\u0026gt; 100°C (148°C according to the manufacturer's data)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eVapor pressure\u003c\/td\u003e\u003ctd\u003e0.09 Pa at 20°C (manufacturer value)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eOdor threshold (+)-cis isomer\u003c\/td\u003e\u003ctd\u003e15 ppb\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eTenacity on blotter\u003c\/td\u003e\u003ctd\u003eabout 1 month\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eUse level (dosage)\u003c\/td\u003e\u003ctd\u003eFine fragrance 7–25%; pH 5.5–7.0\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eSensitization\u003c\/td\u003e\u003ctd\u003eNot sensitizing (RIFM 2015)\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003eBiodegradability\u003c\/td\u003e\u003ctd\u003eReadily biodegradable\u003c\/td\u003e\u003c\/tr\u003e\n\u003ctr\u003e\u003ctd\u003ePatent\u003c\/td\u003e\u003ctd\u003eUS 3,978,108 \/ US 6,455,460 B1 (Roure 1970 (cis), Firmenich 1997 (catalyst), expired) · \u003ca href=\"\/en\/pages\/patentbibliothek#p-hedione-hc\"\u003ePatent Library\u003c\/a\u003e\u003c\/td\u003e\u003c\/tr\u003e\n\u003c\/tbody\u003e\u003c\/table\u003e\n\n\u003ch2\u003eFAQ\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eHow does Hedione® HC differ from classic Hedione®?\u003c\/strong\u003e\u003cbr\u003eSame CAS number, but a higher share of the odor-active (+)-cis isomer. This gives more strength, about 1 month of tenacity on the blotter instead of 2 weeks, and a lower dosage range (7–25% instead of 12–38% in fine fragrance). Classic Hedione® is available \u003ca href=\"\/en\/products\/hedione-firmenich\"\u003ehere in the shop\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow do I dose Hedione® HC?\u003c\/strong\u003e\u003cbr\u003e7–25% of the formula in fine fragrance; 2–10% in shower gel, 0.8–4% in shampoo, 2–5% in candles.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy does pH matter?\u003c\/strong\u003e\u003cbr\u003eIn an alkaline environment the cis isomer converts to the weaker trans form – the same reaction once used deliberately to remove cis impurities. In soap, the effect is therefore lost.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow does Hedione® HC differ from Paradisone?\u003c\/strong\u003e\u003cbr\u003eBoth are cis-enriched variants of the same molecule. Paradisone is nearly isomerically pure but a Firmenich captive material and not for sale. Hedione HC is the strongest Hedione grade available on the open market.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIs Hedione® HC hazardous, or are there IFRA limits?\u003c\/strong\u003e\u003cbr\u003eNo. The RIFM assessment confirms the material is not sensitizing; no IFRA Standard exists.\u003c\/p\u003e\n\n\u003ch2\u003eHazard Information (CLP Labeling)\u003c\/h2\u003e\n\u003cdiv style=\"border:1px solid #d0d0d0;border-radius:8px;padding:16px;max-width:640px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eNot classified as hazardous\u003c\/strong\u003e under Regulation (EC) No 1272\/2008 (CLP). No pictogram, signal word or H-statements required.\u003c\/p\u003e\n\u003cp style=\"font-size:0.85em;color:#666;\"\u003eClassification according to the manufacturer's data; the labelling on the container label is authoritative.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003ch2\u003eImportant Notice\u003c\/h2\u003e\n\u003cp\u003eThis product is a perfumery raw material intended exclusively for fragrance development, creative experimentation, education and the study of perfumery materials.\u003c\/p\u003e\n\u003cp\u003eIt is not a finished cosmetic product.\u003c\/p\u003e\n\u003cp\u003ePlease use responsibly.\u003c\/p\u003e","brand":"dsm-firmenich","offers":[{"title":"20 ml","offer_id":53695322915152,"sku":"HEDHC-20","price":20.0,"currency_code":"EUR","in_stock":true},{"title":"100 ml","offer_id":53704599896400,"sku":"HEDHC-100","price":60.0,"currency_code":"EUR","in_stock":true},{"title":"300 ml","offer_id":53704599929168,"sku":"HEDHC-300","price":150.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0902\/1341\/7296\/files\/HEDIONEHC.jpg?v=1790610034","url":"https:\/\/laborammeer.de\/en\/products\/hedione-hc-dsm-firmenich","provider":"Labor am Meer","version":"1.0","type":"link"}